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Linadus M XR 5/1000mg Tablet 1 Strip
Linadus-M XR 1000
Composition: Linagliptin + Metformin Hydrochloride (Extended Release)
Indication: Type 2 Diabetes Mellitus
- Always take with food.
- Continue diet and exercise as advised.
- Carry a sugar source in case of hypoglycemia.
- Inform healthcare providers before any surgery.
- Immediately report symptoms of lactic acidosis (rapid breathing, nausea, abdominal pain).
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✅ Description:
Linadus-M XR 1000 is a fixed-dose combination of linagliptin and metformin, used to improve glycemic control in adults with type 2 diabetes, particularly when dual therapy is appropriate. It helps prevent complications like nephropathy, retinopathy, and cardiovascular events.
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✔️ Composition
Linagliptin + Metformin Hydrochloride
✔️ Mechanism of Action
Metformin: Lowers glucose production in the liver, slows intestinal absorption of glucose, and enhances insulin sensitivity.
Linagliptin: A DPP-4 inhibitor that prolongs incretin activity, enhancing insulin secretion and decreasing glucagon levels in a glucose-dependent manner.
Together, they target both fasting and postprandial glucose levels for better blood sugar control.
✔️ Dosage & Administration
Adults (Extended-Release Tablets):
Individualized dosing based on current therapy and tolerability.
Maximum: Linagliptin 5 mg + Metformin 2000 mg per day.
It should be taken with meals to minimize gastrointestinal side effects.
Missed Dose: Take as soon as remembered. If it’s close to the next dose, skip the missed one. Do not double-dose.
✔️ Renal Dose Adjustment
eGFR <30 mL/min/1.73 m²: Contraindicated
eGFR 30–45: Do not initiate; reassess if already on therapy
Monitor renal function before starting and periodically thereafter.
✔️ Storage ConditionContraindications
- Known hypersensitivity to components
- Type 1 diabetes or diabetic ketoacidosis
- Severe renal or hepatic impairment
- Acute conditions that may affect kidney function (e.g., dehydration, sepsis)
- Excessive alcohol use
- Pregnancy and lactation (use only if clearly needed)
✔️ Side Effects
Very common (>10%): Hypoglycemia (with sulfonylureas)
Common (1–10%): Diarrhea, nasopharyngitis, headache, nausea
Others (Frequency not defined): Pancreatitis, allergic reactions, decreased appetite, vomiting, pruritus, cough
✔️ Drug Interactions
Linagliptin: Affected by CYP3A4 and P-gp modulators (e.g., ritonavir, rifampicin).
Metformin: Increased lactic acidosis risk with alcohol, iodinated contrast agents, and cationic drugs (e.g., cimetidine). Monitor renal function closely.
✔️ Precautions & Warnings
Monitor for signs of lactic acidosis, pancreatitis, or hypoglycemia.
- Temporarily discontinue before contrast imaging or surgery.
- Caution in the elderly, the renally impaired, or those with heart failure.
- In breastfeeding, metformin appears in breast milk; linagliptin data are lacking—assess risk-benefit.
✔️ Storage:
Keep in a cool & dry place (below 30°C), protected from light & moisture. Keep out of the reach of children.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
